I have been using MiKTeX for a couple of years. I don’t know whether it is “wise” to insist on using it. Could you give me a list of advantages of TeX Live over MiKTeX?
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(Not meant to be a complete answer, just an addition to others.)
TeX Live provides more secure defaults than MiKTeX and probably pays more attention to security in general. For example, section 3 of this paper describes a simple way to make document (or bibtex database, or package) viruses which would almost make MS-Word look as secure alternative 😉 This attack doesn’t work with TeX Live’s default settings, regardless of the platform (Windows or other).
Not completely unrelated, TeX Live is designed to support multi-user systems, including being installed on a servers and used on network clients, possibly with mixed architectures and OSes. (Which may be totally irrelevant to the OP, but mentioned only for information.)